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Advanced Respiratory Care Pharmacology

RT 240

Advanced Respiratory Care Pharmacology

RT 240

Course Description

Prerequisites: Prerequisites: RT 207, RT 212, RT 214, RT 216, RT 226, RT 229, RT 231.

Concurrent enrollment in RT 211, RT 234, RT 244, RT 246. Presents the theory and application of advanced respiratory care pharmacology as it relates to cardiopulmonary pathophysiology. (45-0)

Outcomes and Objectives

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Define Pharmacology and Pharmacy.
  • Explain the five different names that may be given to drugs.
  • Describe the three basic phases of drug action.
  • Describe the various routes of drug administration.
  • Explain those factors controlling the Pharmacokinetic Phase.
  • Define those terms describing drug-receptor interaction.
  • Define those terms describing drug interactions.
  • Explain the Therapeutic Index (TI).
  • Calculate drug dosages from:

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Define the term antibiotic.
  • Describe the modes of action of antibiotics.
  • Define the following terms in regard to the use of antibiotics:
  • For each of the following groups of antibiotics, give representative examples, state the mode of action, precautions or hazards, and uses:
  • Explain the historical significance of Sulfonamides.
  • Describe the mode of action and uses of TMP-SMZ.
  • Describe the mode of action, hazards and toxicity, and use of Amphotericin B.
  • Explain the use of Nystatin.
  • Explain the two basic principles of drug treatment for TB.
  • List those drugs used in the nine-month treatment of TB.
  • Explain how exposure to the TB organism or a positive tuberculin reaction may be managed.
  • Explain three specific problems viral infections pose.
  • Describe the mechanism of viral infection and replication.
  • Describe the mechanisms of action of anti-viral agents and give a representative example.
  • Explain the use of the following agents:
  • Describe the use of aerosolized anti-infectives in respiratory care.
  • Explain the rationale for the use of aerosolized anti-infectives.

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Describe the physiology of neuromuscular junction.
  • For both nondepolarizing and depolarizing neuromuscular blockers:

Demonstrate, through successful completion of written examination the ability to:

Objectives:

  • Describe the mechanism of action, indications for each of the five major diuretic groups.
  • Describe the adverse effects of the Thiazide and Loop Diuretics.

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Describe the basic organization of the Central and Peripheral nervous systems.
  • Define the following terms:
  • Characterize the parasympathetic branch in terms of:
  • Explain the mechanism of action for parasympathomimetics:
  • For parasympatholytics, explain:
  • Characterize the sympathetic branch in terms of:
  • Explain the activity of the sympathetic receptor types:
  • Describe the autonomic effects in the cardiopulmonary system.
  • Explain how the automatic control of the lung is mediated through:

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Describe the clinical applications for the use of adrenergic bronchodilators.
  • Describe the structural- activity relations of the following:
  • Describe the mode of action of adrenergic bronchodilators.
  • For each of the following agents, state the receptor activity, onset, peak, and duration of action, dosage and dosage interval, brand name:
  • Describe the advantages of the inhalation route for administration of adrenergic bronchodilators.
  • State the adverse side effects of adrenergic bronchodilators.

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Describe the history and development of the parasympatholytic agents.
  • Describe the mechanism (mode) of action for:
  • Explain the concept of vagally-mediated reflex bronchoconstriction, mucus production, mast cell degranulation, and its parasympatholytic blockade.
  • Describe the role of topical anesthetics in the inhibition of the vagally-mediated reflex.
  • Explain the role of C-GMP in the autonomic control of the lung.
  • Differentiate the tertiary and quaternary forms of the anticholinergics in terms of absorption and distribution.
  • Describe the site of action of the parasympatholytics.
  • Describe the pharmacologic effects of:
  • Explain the side effects of:
  • Explain the clinical application of:
  • Explain the effects of various plasma levels of theophylline.
  • Explain why monitoring plasma levels of theophylline is important.
  • Describe those factors that effect the elimination of theophylline.
  • State the trade name, generic name, strength, dosage, onset, peak, and duration of action of the following:

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • For each of the classifications of cardiovascular agents and their representative examples, state the trade name, mechanism of action, indications, dosages, and precautions.

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Describe the function of the following secretory structures of the Mucociliary System:
  • Explain the characteristic function of the Ciliary System.
  • Describe the nature of normal mucus secretion.
  • Describe the effects of various disease states on mucus.
  • Describe the physical properties of mucus.
  • Define the following terms:
  • Explain the three general mechanisms of action for mucolytics.
  • For acetylcysteine, explain the following:
  • Describe the effect of bland aerosols on mucus.
  • Explain the use of surface active agents in the treatment of:
  • For Dornase Alpha (Pulmozyme), Explain the following:

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Describe the use of the following agents, in cold remedies:
  • Explain the advantages and disadvantages of topical vs systemic application of decongestants.
  • Identify common representative agents from each class listed in objective 1.
  • Describe the mechanism of action and potential side effects of the agents listed in objective 1.

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Identify three types of hormones produced by the adrenal cortex.
  • Describe the production and control of endogenous conrticosteroids.
  • Explain the function of endogenous corticosteroids.
  • Explain the concept of adrenal suppression and its impact on the use of exogenous glucocrticoids.
  • Describe the daily production of endogenous glucocorticoids in terms of plasma levels.
  • Explain the general mechanism of action, anti-inflammatory action, and the effect on Beta-receptors of glucocorticoids.
  • State the generic name, trade name, and standard dosage of the corticosteroids covered in class.
  • Describe the side-effects, hazards, and precautions in the use of both aerosolized and systemic glucocorticoids.
  • Describe the clinical application of corticosteroids in respiratory care.

Demonstrate, through successful completion of written examination, the ability to:

Objectives:

  • Describe the pathophysiology of asthma.
  • Explain the allergic asthmatic response.
  • Describe the role of each of the following in humoral immunity:
  • Explain the mode of action and clinical application of cromolyn sodium and nedocromil sodium.
  • Identify by trade name various forms of cromolyn sodium and nedocromil sodium.
  • Describe the dosage regulation and side effects of cromolyn sodium and nedocromil sodium.
  • Describe the mode of action, side effects, and clinical uses of: