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Organic Biochemistry

CHM 221

Organic Biochemistry

CHM 221

Course Description

Prerequisites: Prerequisites: READING LEVEL 2 and WRITING LEVEL 2 and MATH LEVEL 5, and (BIO 171 or CHM 210).

Addresses the major human metabolic pathways from an enzymatic perspective. Relies heavily on the major classes of organic compounds and the interrelationships of biologically active compounds. Designed for students interested in careers in health related fields, biochemistry, medicine or pharmacy. (45-0)

Outcomes and Objectives

Communicate effectively

Objectives:

  • Demonstrate understanding by reading, speaking, and writing.
  • Employ critical writing and active listening to obtain or convey information.
  • Collect and analyze data.
  • Identify trends, solve problems, and conclude logically by integrating concepts.

Apply chemical principles to biochemical systems

Objectives:

  • Explain the basic principles of ionic and covalent bonding.
  • Describe the importance of pH and its relationship to the reactivity and stability of molecules.
  • Explain the significance of hydrogen bonding to biochemical molecules.
  • Explain the first and second laws of thermodynamics, coupling of reactions, catabolic, anabolic, exergonic and endergonic reactions.

Apply organic chemistry principles to biochemical systems

Objectives:

  • Draw and name functional groups and use their chemical properties to predict the reactivity and physical characteristics of molecules.
  • Recognize how functional groups in biochemically relevant macromolecules are inter-converted.
  • Explain the molecular structures of functional groups in terms of enantiomers, chiral and achiral centers, stereoisomers, isomers and conformers.

Apply principles of enzyme kinetics to biochemical systems

Objectives:

  • Explain how enzymes are specific and selective catalysts with reference to the chemical properties of amino acids and prosthetic groups.
  • Define activation energy and describe how it is related to reaction rates, free energy and bonding energy.
  • Describe the Michaelis-Menton and allosteric model for enzyme kinetics to calculate Km and Vmax.
  • Recognize the importance of pH, temperature, salt concentration, enzyme concentration, substrate concentration and inhibitors in regulating enzymatic activity.
  • Explain the differences between competitive, non-competitive and uncompetitive inhibitors and how these can be identified using enzyme kinetics and Lineweaver-Burke plots.
  • Describe the simple classification of enzymes by their function.

Describe cellular process in a biochemical system

Objectives:

  • Carbohydrate metabolism:
  • Fat metabolism:
  • Nitrogen metabolism:
  • Cell signaling / communication: